GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12436436 | 1 | rs12436436 | chr14:24381515 | DHRS4 | chr14:24422965-24475615:+ | -0.17 | -3.45 | 0.00058 | Bipolar disorder |
| BRCA | cis | rs12436436 | 1 | rs12436436 | chr14:24381515 | NGDN | chr14:23938898-23947401:+ | -0.19 | -3.42 | 0.00066 | Bipolar disorder |
| BRCA | cis | rs3105593 | 1 | rs12438305 | chr15:50912454 | SPPL2A | chr15:50999739-51057910:- | 0.15 | 5.38 | 9.32E-8 | QT interval |
| BRCA | cis | rs2404602 | 1 | rs12441433 | chr15:76816015 | SCAPER | chr15:76640529-77197744:- | -0.18 | -6.32 | 3.89E-10 | Blood metabolite levels |
| BRCA | cis | rs2404602 | 1 | rs12443137 | chr15:76840832 | SCAPER | chr15:76640529-77197744:- | -0.16 | -5.84 | 6.89E-9 | Blood metabolite levels |
| BRCA | cis | rs4889609 | 1 | rs12445650 | chr16:31044897 | HSD3B7 | chr16:30996519-31000473:+ | 0.24 | 7.38 | 3.28E-13 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs12445650 | chr16:31044897 | MYST1 | chr16:31128985-31142713:+ | 0.2 | 7.37 | 3.44E-13 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs12445650 | chr16:31044897 | ORAI3 | chr16:30960405-30966258:+ | 0.1 | 3.63 | 0.000302 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs12445650 | chr16:31044897 | SETD1A | chr16:30968615-30995981:+ | 0.11 | 3.46 | 0.000563 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs12445650 | chr16:31044897 | ZNF689 | chr16:30614701-30621682:- | 0.11 | 3.54 | 0.00041 | Response to metformin (IC50) |
| BRCA | cis | rs12457810 | 1 | rs12457810 | chr18:9088650 | TWSG1 | chr18:9334765-9402417:+ | 0.21 | 3.96 | 7.94E-5 | Age-related hearing impairment (interaction) |
| BRCA | cis | rs3760982 | 1 | rs12460161 | chr19:44293986 | LYPD5 | chr19:44300080-44324808:- | -0.16 | -4.41 | 1.16E-5 | Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs12460161 | chr19:44293986 | ZNF155 | chr19:44488355-44502477:+ | -0.14 | -3.74 | 0.000194 | Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs12460161 | chr19:44293986 | ZNF404 | chr19:44376516-44384288:- | -0.21 | -5.69 | 1.62E-8 | Breast cancer |
| BRCA | cis | rs11083475 | 1 | rs12462270 | chr19:39201488 | LGALS7 | chr19:39261608-39264157:- | -0.19 | -5.88 | 5.33E-9 | Heart rate |